Skip to content
Norton & Elaine Sarnoff Center for Jewish Genetics Logo
  • Home
  • About Us
    • Board Members
    • Staff
  • Genetic Disorders
    • Types of Genetic Disorders
    • Jewish Genetic Disorder FAQs
    • Rabbinical Insights
  • Hereditary Cancer
    • BRCA Mutations
    • Lynch Syndrome
    • Assess Your Risk
    • Cancer FAQs
    • Cancer Resources
  • Resources
    • Family Health History
    • Teach Jewish Genetics
    • For Medical Professionals
    • Personal Stories
    • Blog
    • Events
  • Donate
  • Get Screened

X-linked Severe Combined Immunodeficiency (X-SCID)

X-linked severe combined immunodeficiency (X-SCID) is an inherited condition of the immune system that causes recurrent and persistent infections, particularly in males.

Symptoms can begin within the first months of life and can be life-threatening. 

This condition is caused by pathogenic (disease-causing) variants in the IL2RG gene and exhibits X-linked recessive inheritance. This means that the mother must be a carrier to have a 50% chance of their sons having the condition and their daughters being carriers. Carriers typically do not experience any symptoms. 

Resources:  

Genetic and Rare Diseases Information Center (GARD)

Immune Deficiency Foundation

International Patient Organization for Primary Immunodeficiencies

Revised June 2022

Share this
Tweet this
Email this

The Norton & Elaine Sarnoff Center for Jewish Genetics is a supporting foundation of the Jewish United Fund, and is supported in part by the Michael Reese Health Trust.

30 S Wells
Chicago, IL 60606
312-357-4718
jewishgenetics@juf.org

About
  • About Us
  • Genetic Disorders
  • Hereditary Cancer
  • Donate
Resources
  • Medical Professionals
  • Teach Jewish Genetics
  • Events

©2023 Norton & Elaine Sarnoff Center for Jewish Genetics

Page load link
Go to Top