The hereditary cancer test we offer is single gene testing, not a polygenic risk score. A polygenic risk score estimates a person’s likelihood of developing a certain disease based on many small genetic variations across their DNA. Each of these variations contributes a tiny amount to overall risk, and when combined, they can provide insight into a person’s inherited susceptibility to conditions like heart disease, diabetes, or cancer. Polygenic risk scores show probabilities, not certainties as lifestyle and environment also play major roles in health.